Aspirin is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antiinflammatory compound that inhibits cox1. The merck index online chemicals, drugs and biologicals. Experiment 22 synthesis of aspirin and oil of wintergreen goals. The number of the compound is listed below, so you can easily look it up in the beginning of section three.
Certificate of analysis coa specification sheet pdf. If you know that your compound has a melting point of 77 degrees, the index will list several compounds that match these criteria. On the anomalous melting point and the decomposition of acetylsalicylic acid. Your instructor will demonstrate the use of this apparatus. I predict that the melting point high range is due to the fact that multiple compounds. If impurities are present in your crude sample, the melting point range for your product will be lower than the range of pure aspirin. Salicylamide is the common name for the substance ohydroxybenzamide, or amide of salicyl. Obtain two capillary tubes that are sealed at one end. Pittsburgh pa section on practical pharmacy and dispensing, a. Please try againthere was an issue with your search, no terms could be found. The search on this page works by searching the content. The melting point is the temperature in which aspirin will go from a solid to a liquid.
The identification of unknown compounds is an important task of the organic chemist. Load one tube with your synthesized sample as follows. Appendixes include a chronology of the drug that starts in 400 b. The crc handbook of chemistry and physics hbcp contains over 700 tables in over 450 documents which may be divided into several pages, all categorised into 17 major subject areas.
Fusion melting point data from nist standard reference database 69. The problem with getting a value for the melting point of an organic substance is the purity of the material. The merck index online offers the same highly authoritative information as the print edition in a convenient and easily searchable full text database. Aspirin given shortly after a heart attack decreases the risk of death. Salicylamide is used in combination with both aspirin and caffeine in the overthecounter pain remedies. Section disposal considerations chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. The search on this page works by searching the content of each page individually, much like any web search. Dont heat too fast aspirin is only found in individuals who have consumed this drug. Measure the melting temperature of the product using melting temperature apparatus the procedure will have to be split over more than one lesson because the crystals. Make sure to record the crc value before you leave the lab. Us epa guidelines for the classification determination are listed in 40 cfr parts 261. Chemical properties aspirin should it be the ideal.
Synthesis of aspirin and melting point determination namehood. When available, the triple point pressure is listed. For more information, see handbook of environmental fate and exposure data. Determine the melting point of the aspirin sample fill a capillary melting point tube to a depth of 0. This book contains eight freestanding activities that can be used singly or as a coherent package in a wide range of teaching and learning situations for both academic and vocational courses. A purine alkaloid that occurs naturally in tea and coffee. Aspirin melting point essay medicine and health articles. Advanced preparation and the notebook before coming to the laboratory you will find that some advanced preparation can save significant time and effort in the laboratory. Caffeine is a trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A melting point capillary tube with 12cm depth of fine crystals was loaded. Recrystallise the aspirin in the minimum volume of a mixture of ethanol to water 1. Also, your melting point range may be greater than 2 degrees. In this experiment, you will measure the melting point of your synthesized asa product, salicylic acid, a crushed aspirin tablet, and pure asa from a manufacturer. Dont heat too fast aspirin product had a melting point range of 110.
A pure sample of a substance will melt at a sharply defined temperature, an impure sample will show a larger range. A copy of the crc handbook is available in the laboratory. Pdf design synthesis and crystallization of acetaminophen. Aspirin has different chemical features than any other molecules. Solubility is defined as the concentration of the compound in a solution that is in equilibrium with a solid phase at the specified temperature. Today you will use salicylic acid as the starting material for acetyl salicylic acid aspirin. They also include cautions for giving aspirin to children, older people, and animals, and finally consider aspirin s various brands and forms as well as its alternatives. Typically, tables of melting points are for standard. Mar 01, 2007 the problem with getting a value for the melting point of an organic substance is the purity of the material. The values of melting point of acetaminophen are in the range of 168172 0 c. At the melting point the solid and liquid phase exist in equilibrium.
The melting point of a substance depends on pressure and is usually specified at a standard pressure such as 1 atmosphere or 100 kpa. Range of the melting point indicate the purity of the compound. It has a role as a central nervous system stimulant, a ryanodine receptor modulator, an ec 3. Miscellaneous the melting point of acetylsalicylic acid published by permission of the chairman of the committee of revision, u. Specific inflammatory conditions which aspirin is used to treat include kawasaki disease, pericarditis, and rheumatic fever. The melting point range of pure aspirin is 8140 c and the melting point range of the salicylic acid starting material is 158161 c. The melting point temperature ranges were 126oc2oc and 129oc4oc for the crude and recrystallized aspirin samples, respectively. Manual thin layer chromatography and melting point. Aspirin is an orally administered nonsteroidal antiinflammatory agent. The melting point of a substance depends on pressure and is usually specified at a standard pressure such as 1 atmosphere or 100 kpa when considered as the temperature of. The aspirin crystals were observed under the microscope and were drawn on the result sheet.
Reduce the sample to a fine powder by using mortar and pestle. Use a boiling water bath to calibrate the thermometer in your melting point apparatus as demonstrated by your instructor. The usefulness of functional groups will be illustrated as well as the use of nmr, ir, and melting point in characterizing a product. Bulletin of the chemical society of japan 1950, 23 1, 2325. A complete listing of abbreviations appears on the introductory portions of the tables. The melting point or, rarely, liquefaction point of a substance is the temperature at which it changes state from solid to liquid. C a list of products containing aspirin, acetaminophen, or ibuprofen. Aspirin, also known as acetylsalicylic acid asa, is a medication used to reduce pain, fever, or inflammation. Nist chemistry webbook the national institute of standards and technology nist uses its best efforts to deliver a high quality copy of the database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. The advanced preparation will vary depending on the nature of the experiment, but some general rules will be applicable to all experiments. Experiment 22 synthesis of aspirin and oil of wintergreen. Due to its wide range, and lower value than that of the theoretical melting point of 6c, it was assessed that the prepared aspirin was impure.
Aqueous solubility of inorganic compounds at various temperatures the solubility of over 300 common inorganic compounds in water is tabulated here as a function of temperature. Experimental synthesis of aspirin and melting point purity. Aspirin, an acetyl derivative of salicylic acid, is a white, crystalline, weakly acidic substance, with a melting point of 6 c 277 f, and a boiling point of 140 c 284 f. Due to the limited number of instruments available, you may. Aspirin or acetylsalicylic acid acetosal is a drug in the family of salicylates, often used as an analgesic against minor pains and aches, antipyretic against fever, and antiinflammatory. This agent exhibits analgesic, antipyretic, and anticoagulant properties.
Aspirin is also used longterm to help prevent further heart attacks, ischaemic. Salicylamide is a nonprescription drug with analgesic and antipyretic properties. The notation tp indicates the temperature where solid, liquid, and gas are in equilibrium at a pressure greater than one atmosphere i. You are not within the network of a subscribing institution. Calculate the average melting temperature, and compare this temperature to the melting point for salicylic acid found in the crc handbook of chemistry and physics. Acetylsalicylic acid binds to and acetylates serine residues in cyclooxygenases, resulting in decreased synthesis of prostaglandin, platelet aggregation, and inflammation. In this twoweek experiment the important area of organic chemistry will be illustrated by the preparation and characterization of two compounds. Finally, in section 3, melting points of various substances are listed in ascending order.
Guide to the crc handbook of chemistry and physics physical. Results at the end of the experiment, the result gotten should be a result of 40 60 % yield and a melting point that is around the theoretical melting point of aspirin, which is 5ac 6ac. The experimental melting point range of aspirin was determined to be 122 2c. Beneficial and toxic effects of aspirin crc press book. The merck index online will be updated regularly with accurate information curated by experts.
Melting point depends on pressure, so it should be specified. Recently, aspirin has been found to be associated with a decreased risk of heart disease and other newly found health benefits. Place the capillary tube in the melting point apparatus. Handbook for organic chemistry lab, sections on writing lab reports chapter 6, melting point chapter 10, and thin layer chromatography chapter 7. However, it produces allergylike and toxic effects in many individuals. The purity of sample was tested by determining its melting point range. The data in the table have been derived from many sources, including both the primary literature and evaluated compilations. It contains over 11,500 monographs including historic records not available in the print edition. Cookie policy crc handbook of chemistry and physics.